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Protein Coding Gene : Nde1 nudE neurodevelopment protein 1
Primary Identifier  MGI:1914453 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  67203
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables identical protein binding activity and microtubule binding activity. Involved in centrosome duplication and neuron migration. Acts upstream of or within microtubule nucleation; nervous system development; and vesicle transport along microtubule. Located in spindle pole centrosome and synapse. Is expressed in several structures, including brain; cardiovascular system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1).
PHENOTYPE: Homozygous null mutants have a small brain with fewer neurons in the cerebral cortex and very thin superficial cortical layers. [provided by MGI curators]
  • synonyms:
  • mNudE,
  • RIKEN cDNA 2810027M15 gene,
  • nudE neurodevelopment protein 1,
  • 2810027M15Rik,
  • AU042936,
  • expressed sequence AU042936,
  • Nde1,
  • AW822251,
  • expressed sequence AW822251,
  • MGI:2146676,
  • MGI:2146576
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