| First Author | Kanagawa O | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 7 | Pages | 3919-23 |
| PubMed ID | 10725755 | Mgi Jnum | J:61407 |
| Mgi Id | MGI:1354877 | Doi | 10.4049/jimmunol.164.7.3919 |
| Citation | Kanagawa O, et al. (2000) Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci. J Immunol 164(7):3919-23 |
| abstractText | Nonobese diabetic (NOD) mice carrying a segment of chromosome flanking the disrupted IFN-gamma receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-gammaR-deficient genotype from the diabetes-resistant phenotype. These results indicate that the protection of NOD mice from the development of diabetes is not directly linked to the defective IFN-gamma receptor gene but, rather, is influenced by the presence of a diabetes-resistant gene(s) closely linked to the IFN-gammaR loci derived from the 129 mouse strain. |
