| Primary Identifier | MGI:2140313 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 100155 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ATP hydrolysis activity and single-stranded DNA binding activity. Involved in resolution of meiotic recombination intermediates and synaptonemal complex assembly. Located in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human SHOC1 (shortage in chiasmata 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E9.5. Male mice homozygous for a hypomorphic allele exhibit a lack of spermatozoa, reduced testis weight and size, increased male germ cell apoptosis, and abnormal male meiosis with defective chiasmata formation and chromosomal synapsis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
