First Author | Bora RS | Year | 2000 |
Journal | FEBS Lett | Volume | 473 |
Issue | 2 | Pages | 169-72 |
PubMed ID | 10812068 | Mgi Jnum | J:62202 |
Mgi Id | MGI:1858568 | Doi | 10.1016/s0014-5793(00)01524-6 |
Citation | Bora RS, et al. (2000) Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene. FEBS Lett 473(2):169-72 |
abstractText | The acetyl-CoA transporter gene (Acatn) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O-acetylation of sialic acid residues on gangliosides. O-Acetylated gangliosides have been found to play important roles in tissue development and organization during early embryonic stages. We have cloned the gene for mouse acetyl-CoA transporter. The gene spans approximately 20 kb and is composed of seven exons and six introns. A single transcription initiation site, 371 bp upstream of the ATG start codon, was identified. The promoter region was found to lack a TATA box. However, several potential transcription factor binding motifs such as AP1, AP2, C/EBPalpha, C/EBPbeta, HSF, GATA2 and MZF1 were identified in the promoter region. |