| First Author | Søndergaard E | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 9 | Pages | 2756-2769.e6 |
| PubMed ID | 31775043 | Mgi Jnum | J:314404 |
| Mgi Id | MGI:6715195 | Doi | 10.1016/j.celrep.2019.10.098 |
| Citation | Sondergaard E, et al. (2019) ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination. Cell Rep 29(9):2756-2769.e6 |
| abstractText | B cell development depends on the coordinated expression and cooperation of several transcription factors. Here we show that the transcription factor ETS-related gene (ERG) is crucial for normal B cell development and that its deletion results in a substantial loss of bone marrow B cell progenitors and peripheral B cells, as well as a skewing of splenic B cell populations. We find that ERG-deficient B lineage cells exhibit an early developmental block at the pre-B cell stage and proliferate less. The cells fail to express the immunoglobulin heavy chain due to inefficient V-to-DJ recombination, and cells that undergo recombination display a strong bias against incorporation of distal V gene segments. Furthermore, antisense transcription at PAX5-activated intergenic repeat (PAIR) elements, located in the distal region of the Igh locus, depends on ERG. These findings show that ERG serves as a critical regulator of B cell development by ensuring efficient and balanced V-to-DJ recombination. |
