| First Author | Emirandetti A | Year | 2006 |
| Journal | Brain Res | Volume | 1095 |
| Issue | 1 | Pages | 35-42 |
| PubMed ID | 16714003 | Mgi Jnum | J:110474 |
| Mgi Id | MGI:3640268 | Doi | 10.1016/j.brainres.2006.04.021 |
| Citation | Emirandetti A, et al. (2006) Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy. Brain Res 1095(1):35-42 |
| abstractText | Although synaptic plasticity is a widespread phenomenon, the underlying mechanisms leading to its occurrence are virtually unknown. In this sense, glial cells, especially astrocytes, may have a role in network changes of the nervous system, influencing the retraction of boutons as well as providing a proper perisynaptic environment, thereby affecting the replacement of inputs. Interestingly, the glial reaction does vary between strains of rats and mice. In this sense, we present evidence that C57BL/6J and A/J isogenic mice present different astrocyte reactivity after a peripheral lesion in vivo as well as in vitro, by analyzing primary cell cultures. Such a difference in the glial reaction has a direct influence on in vivo number of pre-synaptic terminals and on in vitro synaptogenesis. |
