Primary Identifier | MGI:1934816 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 104271 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Involved in DNA methylation and retrotransposon silencing. Acts upstream of or within with a positive effect on DNA methylation-dependent heterochromatin formation. Acts upstream of or within several processes, including male gamete generation; regulation of double-strand break repair via homologous recombination; and synaptonemal complex assembly. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators] |