| Primary Identifier | MGI:2388199 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Pdlim3 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| description | Although Pdlim3tm1Krc homozygous mutant mice lack certain key features of human arrhythmogenic RV dysplasia (ARVD), such as arrhythmogenesis and fatty infiltration of the RV wall, their unique cardiomyopathy phenotype does resemble the preferential RV dilation with mild LV dysfunction observed in ARVD (J:69097). |
| molecularNote | The gene was disrupted by insertion of a lacZ-PGK-neo cassette downstream of the translation initation codon. Western blot analysis of skeletal muscle protein from homozygous mutant animals confirmed the absence of gene expression. |
