| First Author | Yu Q | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 1 | Pages | 126-31 |
| PubMed ID | 17579030 | Mgi Jnum | J:149422 |
| Mgi Id | MGI:3848433 | Doi | 10.4049/jimmunol.179.1.126 |
| Citation | Yu Q, et al. (2007) Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection. J Immunol 179(1):126-31 |
| abstractText | Differentiation of CD4+CD8+ double-positive thymocytes into CD8+ single-positive (SP) thymocytes is regulated by TCR and cytokine receptor signals. Previously, we have shown that expression of stabilized beta-catenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8SP thymocytes with a preferential effect on CD8SP thymocytes. In this report, using mice expressing stabilized beta-catenin and mice with T cell specific deletion of beta-catenin, we show that beta-catenin expression augments IL-7Ralpha-chain expression and down-regulates suppressor of cytokine signaling-1 expression in thymocytes undergoing positive selection. Consequently, beta-catenin expression augments IL-7R signaling in thymocytes during positive selection and promotes the development of CD8SP thymocytes. |
