| Primary Identifier | MGI:1916419 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 69169 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables IgM binding activity. Involved in humoral immune response mediated by circulating immunoglobulin; immunoglobulin transcytosis in epithelial cells; and regulation of B cell receptor signaling pathway. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane and trans-Golgi network membrane. Orthologous to human FCMR (Fc mu receptor). PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
