| First Author | Bowakim-Anta N | Year | 2023 |
| Journal | Front Immunol | Volume | 14 |
| Pages | 1023064 | PubMed ID | 36993956 |
| Mgi Jnum | J:334946 | Mgi Id | MGI:7449817 |
| Doi | 10.3389/fimmu.2023.1023064 | Citation | Bowakim-Anta N, et al. (2023) Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs. Front Immunol 14:1023064 |
| abstractText | INTRODUCTION: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown. METHODS: In this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4(+) T cells in vivo, in the absence of intentional antigenic stimulation. RESULTS: Our data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-gamma and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion. CONCLUSION: We conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory. |
