| Primary Identifier | MGI:894696 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 12258 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Predicted to act upstream of or within several processes, including blood coagulation; complement activation, classical pathway; and fibrinolysis. Located in extracellular space. Is expressed in several structures, including genitourinary system; neural ectoderm; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). PHENOTYPE: Mutant mice exhibit an increased vascular permeability compared to controls. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
