| First Author | Hegde R | Year | 1998 |
| Journal | J Biol Chem | Volume | 273 |
| Issue | 14 | Pages | 7783-6 |
| PubMed ID | 9525867 | Mgi Jnum | J:46845 |
| Mgi Id | MGI:1202139 | Doi | 10.1074/jbc.273.14.7783 |
| Citation | Hegde R, et al. (1998) Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem 273(14):7783-6 |
| abstractText | We identified and cloned a novel murine member of the pro-apoptotic Bcl-2 family. This protein, designated Blk, is structurally and functionally related to human Bik and localized to the mitochondrial membrane. Blk contains a conserved BH3 domain and can interact with the anti-apoptotic proteins Bcl-2 and Bcl-xL. Ectopic expression of Blk in mammalian cells induces apoptosis, which can be inhibited by mutations in the BH3 domain and by overexpression of Bcl-2 or Bcl-xL but not by CrmA. The apoptotic activity of Blk is also inhibited by a dominant negative caspase-9, suggesting that Blk induces apoptosis through activation of the cytochrome c-Apaf-1-caspase-9 pathway. |
