| First Author | Angelin B | Year | 2012 |
| Journal | Cell Metab | Volume | 16 |
| Issue | 6 | Pages | 693-705 |
| PubMed ID | 23217254 | Mgi Jnum | J:194168 |
| Mgi Id | MGI:5471159 | Doi | 10.1016/j.cmet.2012.11.001 |
| Citation | Angelin B, et al. (2012) Circulating fibroblast growth factors as metabolic regulators--a critical appraisal. Cell Metab 16(6):693-705 |
| abstractText | The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation. |
