| First Author | Mayeuf-Louchart A | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 14383 |
| PubMed ID | 29085009 | Mgi Jnum | J:287415 |
| Mgi Id | MGI:6415766 | Doi | 10.1038/s41598-017-14596-2 |
| Citation | Mayeuf-Louchart A, et al. (2017) Rev-erb-alpha regulates atrophy-related genes to control skeletal muscle mass. Sci Rep 7(1):14383 |
| abstractText | The nuclear receptor Rev-erb-alpha modulates hepatic lipid and glucose metabolism, adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-alpha is also an important regulator of skeletal muscle mitochondrial biogenesis and function, and autophagy. As such, Rev-erb-alpha over-expression in skeletal muscle or its pharmacological activation improved mitochondrial respiration and enhanced exercise capacity. Here, in gain- and loss-of function studies, we show that Rev-erb-alpha also controls muscle mass. Rev-erb-alpha-deficiency in skeletal muscle leads to increased expression of the atrophy-related genes (atrogenes), associated with reduced muscle mass and decreased fiber size. By contrast, in vivo and in vitro Rev-erb-alpha over-expression results in reduced atrogenes expression and increased fiber size. Finally, Rev-erb-alpha pharmacological activation blocks dexamethasone-induced upregulation of atrogenes and muscle atrophy. This study identifies Rev-erb-alpha as a promising pharmacological target to preserve muscle mass. |
