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Protein Coding Gene : Mcu mitochondrial calcium uniporter
Primary Identifier  MGI:3026965 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  215999
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable calcium channel activity; identical protein binding activity; and uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrion. Part of calcium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and vertebral axis musculature. Orthologous to human MCU (mitochondrial calcium uniporter).
PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired calcium-induced permeability transition pore opening, decreased body size and weight, decreased exercise endurance and decreased grip strength. [provided by MGI curators]
  • synonyms:
  • MGI:2143778,
  • MGI:1917124,
  • AV064928,
  • RIKEN cDNA 2010012O16 gene,
  • gene model 64, (NCBI),
  • expressed sequence AV064928,
  • Ccdc109a,
  • 2010012O16Rik,
  • mitochondrial calcium uniporter,
  • Mcu,
  • coiled-coil domain containing 109A,
  • D130073L02Rik,
  • MGI:2684910,
  • RIKEN cDNA D130073L02 gene,
  • Gm64
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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Interactions

3 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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