| Primary Identifier | IPR031240 | Type | Family |
| Short Name | Latrophilin-2 |
| description | Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: Latrophilin-1 (LPH1), -2 (LPH2), and -3 (LPH3). LPH1 is a brain-specific calcium independent receptor of alpha-latrotoxin (LTX), a neurotoxin present in black widow spider venom which triggers massive exocytosis from presynaptic nerve terminals [, ]. It is the affinity of this form of the receptor for LTX that gives the family its name.Two endogenous ligands for latrophilins have been described, teneurin-2 []and FLRT3 []. LPH1 has been shown to bind Lasso (a splice variant of teneurin-2). LPH1 and Lasso interact across intercellular and synaptic junctions, suggesting an involvement in synaptic functions []. Latrophilins are potential synaptic cell-adhesion molecules that interact trans-synaptically with teneurins and FLRTs []. LPH2 and LPH3, whilst sharing extensive sequence similarity to LPH1, do not bind LTX. LPH1 and LPH3 are expressed in neurons, while LPH2 is ubiquitous []. LPH2 is a component of the epithelial-mesenchymal transition in the heart []and may be involved in breast cancer []. This entry refers to both latrophilin-2. |
