| First Author | Yahata T | Year | 2002 |
| Journal | Genomics | Volume | 80 |
| Issue | 6 | Pages | 601-13 |
| PubMed ID | 12504852 | Mgi Jnum | J:80801 |
| Mgi Id | MGI:2447223 | Doi | 10.1006/geno.2002.7005 |
| Citation | Yahata T, et al. (2002) Cloning of Mouse cited4, a Member of the CITED Family p300/CBP-Binding Transcriptional Coactivators: Induced Expression in Mammary Epithelial Cells. Genomics 80(6):601-13 |
| abstractText | The CITED family proteins bind to CBP/p300 transcriptional integrators through their conserved C-terminal acidic domain and function as coactivators. The 21-kDa mouse Cited4 protein, a novel member of the CITED family, interacted with CBP/p300 as well as isoforms of the TFAP2 transcription factor, coactivating TFAP2-dependent transcription. The cited4 gene consisted of only a single exon located on chromosome 4 at 56.5-56.8 cM flanked by marker genes kcnq4 and scml1. Expression of Cited4 protein was strong and selective in embryonic hematopoietic tissues and endothelial cells. In adult animals, Cited4 showed strong milk cycle-dependent induction in pregnant and lactating mammary epithelial cells. Strong induction of Cited4 expression was also observed in SCp2 mouse mammary epithelial cells during their prolactin-dependent in vitro differentiation. These results implied possible roles for Cited4 in regulation of gene expression during development and differentiation of blood cells, endothelial cells, and mammary epithelial cells. |
