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Publication : Airway hyperreactivity is associated with specific leukocyte subset infiltration in a mouse model of allergic airway inflammation.

First Author  Lukacs NW Year  1996
Journal  Pathobiology Volume  64
Issue  6 Pages  308-13
PubMed ID  9159024 Mgi Jnum  J:40311
Mgi Id  MGI:87652 Doi  10.1159/000164065
Citation  Lukacs NW, et al. (1996) Airway hyperreactivity is associated with specific leukocyte subset infiltration in a mouse model of allergic airway inflammation. Pathobiology 64(6):308-13
abstractText  Airway hyperreactivity is defined as an increased bronchoconstrictor response to physical, pharmacological, or other stimuli. Patients with asthma develop airway hyperreactivity as well as peribronchial inflammation. We employed an established schistosome soluble egg antigen (SEA)-induced murine model of allergic inflammation to examine the temporal relationship between airway hyperreactivity and subset infiltration. Dose response curves of intravenous methacholine were used in mice to characterize airway
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