| Primary Identifier | MGI:1343327 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 259277 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables serine-type endopeptidase activity. Involved in several processes, including keratinocyte proliferation; memory; and neuron projection morphogenesis. Acts upstream of or within synapse organization. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; foregut; heart; hemolymphoid system gland; and skin. Orthologous to human KLK8 (kallikrein related peptidase 8). PHENOTYPE: Homozygotes for a null allele show aberrant synapses and neurons in the hippocampus CA1 field. Homozygotes for another null allele have normal LTP and spatial reference memory but show increased polyspiking in response to repetitive afferent stimulation and enhanced kainite-induced seizure activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
