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Publication : Disc1 variation leads to specific alterations in adult neurogenesis.

First Author  Chandran JS Year  2014
Journal  PLoS One Volume  9
Issue  10 Pages  e108088
PubMed ID  25272038 Mgi Jnum  J:223479
Mgi Id  MGI:5649199 Doi  10.1371/journal.pone.0108088
Citation  Chandran JS, et al. (2014) Disc1 variation leads to specific alterations in adult neurogenesis. PLoS One 9(10):e108088
abstractText  Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder. Here we use two missense Disc1 mouse mutants, described previously with distinct behavioural phenotypes, to demonstrate that Disc1 variation exerts differing effects on the formation of newly generated neurons in the adult hippocampus. Disc1 mice carrying a homozygous Q31L mutation, and displaying depressive-like phenotypes, have fewer proliferating cells while Disc1 mice with a homozygous L100P mutation that induces schizophrenia-like phenotypes, show changes in the generation, placement and maturation of newly generated neurons in the hippocampal dentate gyrus. Our results demonstrate Disc1 allele specific effects in the adult hippocampus, and suggest that the divergence in behavioural phenotypes may in part stem from changes in specific cell populations in the brain.
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