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Protein Domain : Migration and invasion-inhibitory protein

Primary Identifier  IPR031466 Type  Family
Short Name  MIIP
description  Migration and invasion-inhibitory protein (MIIP or IIp45) binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells []. MIIP attenuates mitotic transition, thereby inhibiting glioma progression []. It not only modulates IGFBP-2, but also inhibits cell migration by binding to and inhibiting HDAC6, a class 2 histone deacetylase that deacetylates alpha-tubulin [].

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0 Parent Features

4 Protein Domain Regions