| First Author | Lehr L | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 19 | Pages | 4661-6 |
| PubMed ID | 16876797 | Mgi Jnum | J:112155 |
| Mgi Id | MGI:3655594 | Doi | 10.1016/j.febslet.2006.07.037 |
| Citation | Lehr L, et al. (2006) The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture. FEBS Lett 580(19):4661-6 |
| abstractText | In rodent brown adipose tissue, the beta-adrenergic signaling is believed, by an action on PGC-1alpha, to control UCP1 expression and mitochondriogenesis. We addressed this hypothesis using beta(1)/beta(2)/beta(3)-adrenoceptor knockout (beta-less) brown adipocytes in primary culture. In these cells: (a) proliferation and differentiation into multilocular cells were normal; (b) UCP1 mRNA expression was dramatically decreased (by 93%), whereas PGC-1alpha and mtTFA mRNA expressions were not; (c) UCP1, PGC-1alpha and COX IV protein expressions were decreased by 97%, 62% and 22%, respectively. Altogether the data show a dissociation between the control of UCP1, which is mostly beta-adrenoceptor-dependent and that of PGC-1alpha and of mitochondriogenesis which are not. |
