| First Author | Arai S | Year | 2005 |
| Journal | EMBO J | Volume | 24 |
| Issue | 10 | Pages | 1863-73 |
| PubMed ID | 15889154 | Mgi Jnum | J:98498 |
| Mgi Id | MGI:3578583 | Doi | 10.1038/sj.emboj.7600654 |
| Citation | Arai S, et al. (2005) Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J 24(10):1863-73 |
| abstractText | Polycomb group (PcG) proteins participate in DNA-binding complexes with gene-repressing activity, many of which have been highlighted for their involvement in hematopoiesis. We have identified a putative PcG protein, termed MBT-1, that is associated with Rnf2, an in vivo interactor of PcG proteins. MBT-1 structurally resembles the H-L(3)MBT protein, whose deletion is predicted to be responsible for myeloid hematopoietic malignancies. The human MBT-1 gene is located on chromosome 6q23, a region frequently deleted in leukemia cells, and shows a transient expression spike in response to maturation-inducing stimuli in myeloid leukemia cells. MBT-1(-/-) myeloid progenitor cells exhibit a maturational deficiency but maintain normal proliferative activities. This results in the accumulation of immature myeloid progenitors and hence, a marked decrease of mature myeloid blood cells, causing the MBT-1(-/-) mice to die of anemia during a late embryonic stage. Together, we conclude that MBT-1 specifically regulates the maturational advancement of myeloid progenitor cells during transitions between two developmental stages. We also show that MBT-1 appears to influence myelopoiesis by transiently enhancing p57(KIP2) expression levels. |
