| First Author | Butovsky O | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 1 | Pages | 131-43 |
| PubMed ID | 24316888 | Mgi Jnum | J:207912 |
| Mgi Id | MGI:5559932 | Doi | 10.1038/nn.3599 |
| Citation | Butovsky O, et al. (2014) Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 17(1):131-43 |
| abstractText | Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia versus myeloid and other immune cells. Of the 239 genes, 106 were enriched in microglia as compared with astrocytes, oligodendrocytes and neurons. This microglia signature was not observed in microglial lines or in monocytes recruited to the CNS, and was also observed in human microglia. We found that TGF-beta was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adult microglia and that microglia were absent in the CNS of TGF-beta1-deficient mice. Our results identify a unique microglial signature that is dependent on TGF-beta signaling and provide insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease. |
