| First Author | Meyers JH | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 5 | Pages | 455-64 |
| PubMed ID | 15793576 | Mgi Jnum | J:261838 |
| Mgi Id | MGI:6158812 | Doi | 10.1038/ni1185 |
| Citation | Meyers JH, et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6(5):455-64 |
| abstractText | The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1-Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation. |
