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Protein Coding Gene : Parg poly (ADP-ribose) glycohydrolase
Primary Identifier  MGI:1347094 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  26430
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables poly(ADP-ribose) glycohydrolase activity. Acts upstream of or within DNA damage response and detection of bacterium. Located in cytosol and nucleus. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human PARG (poly(ADP-ribose) glycohydrolase).
PHENOTYPE: Mice homozygous for one allele of this gene are hypersensitive to alkylating agents and ionizing radiation and susceptible to streptozotocin induced diabetes and endotoxic shock. Mice homozygous for a second allele display embryonic lethality and fail tohatch from the zona pellucida. [provided by MGI curators]
  • synonyms:
  • poly (ADP-ribose) glycohydrolase,
  • MGI:2145628,
  • expressed sequence AI413217,
  • Parg,
  • AI413217
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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5 Pathways

Trail: ProteinCodingGene

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Phenotype

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Disease

Mouse features --> Human diseases

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