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Publication : Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.

First Author  Kremer T Year  2007
Journal  FEBS Lett Volume  581
Issue  24 Pages  4727-33
PubMed ID  17869247 Mgi Jnum  J:126832
Mgi Id  MGI:3762080 Doi  10.1016/j.febslet.2007.08.070
Citation  Kremer T, et al. (2007) Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. FEBS Lett 581(24):4727-33
abstractText  Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non-transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals.
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