| First Author | Meissburger B | Year | 2011 |
| Journal | EMBO Mol Med | Volume | 3 |
| Issue | 11 | Pages | 637-51 |
| PubMed ID | 21853531 | Mgi Jnum | J:205648 |
| Mgi Id | MGI:5545969 | Doi | 10.1002/emmm.201100172 |
| Citation | Meissburger B, et al. (2011) Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma. EMBO Mol Med 3(11):637-51 |
| abstractText | Obesity is a well-known risk factor for the development of secondary complications such as type 2 diabetes. However, only a part of the obese population develops secondary metabolic disorders. Here, we identify the transcription factor retinoid-related orphan receptor gamma (RORgamma) as a negative regulator of adipocyte differentiation through expression of its newly identified target gene matrix metalloproteinase 3. In vivo differentiation of adipocyte progenitor cells from Rorgamma-deficient mice is enhanced and obese Rorgamma(-/-) mice show decreased adipocyte sizes. These small adipocytes are highly insulin sensitive, leading to an improved control of circulating free fatty acids. Ultimately, Rorgamma(-/-) mice are protected from hyperglycemia and insulin resistance in the state of obesity. In adipose stromal-vascular fraction from obese human subjects, Rorgamma expression is correlated with adipocyte size and negatively correlated with adipogenesis and insulin sensitivity. Taken together, our findings identify RORgamma as a factor, which controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. RORgamma might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance. |
