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Publication : Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE.

First Author  Hatfield JK Year  2015
Journal  Cell Immunol Volume  297
Issue  2 Pages  69-79
PubMed ID  26163773 Mgi Jnum  J:233049
Mgi Id  MGI:5780647 Doi  10.1016/j.cellimm.2015.06.006
Citation  Hatfield JK, et al. (2015) Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE. Cell Immunol 297(2):69-79
abstractText  Innate lymphoid cells are immune cells that reside in tissues that interface with the external environment and contribute to the first line defense against pathogens. However, they also have roles in promoting chronic inflammation. Here we demonstrate that group 3 ILCs, (ILC3s - CD45+Lin-IL-7Ralpha+RORgammat+), are normal residents of the meninges and exhibit disease-induced accumulation and activation in EAE. In addition to production of the pro-inflammatory cytokines IL-17 and GM-CSF, ILC3s constitutively express CD30L and OX40L, molecules required for memory T cell survival. We show that disease-induced trafficking of transferred wild type T cells to the meninges is impaired in ILC3-deficient Rorc-/- mice. Furthermore, lymphoid tissue inducer cells, a c-kit+ ILC3 subset that promotes ectopic lymphoid follicle development, a hallmark of many autoimmune diseases, are reduced in the meninges of EAE-resistant c-kit mutant Kit(W/Wv) mice. We propose that ILC3s sustain neuroinflammation by supporting T cell survival and reactivation in the meninges.
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