| First Author | Gallucci RM | Year | 1994 |
| Journal | Alcohol Clin Exp Res | Volume | 18 |
| Issue | 3 | Pages | 625-31 |
| PubMed ID | 7943666 | Mgi Jnum | J:19235 |
| Mgi Id | MGI:67425 | Doi | 10.1111/j.1530-0277.1994.tb00921.x |
| Citation | Gallucci RM, et al. (1994) Effects of ethanol consumption on enriched natural killer cells from C57BL/6 mice. Alcohol Clin Exp Res 18(3):625-31 |
| abstractText | Ethanol (20% w/v) given to female, C57BL/6 mice in their drinking water was previously shown to suppress natural killer (NK) cell cytolytic activity in a mixed splenocyte population. The present study was designed to examine the hypothesis that ethanol consumption independently results in inhibition of NK cell cytolytic activity. Mice were given 20% w/v ethanol in the drinking water for 2 weeks, and splenic NK cells were enriched up to 88% based on surface expression of NK1.1. Cytolytic activity of these freshly enriched NK cells from ethanol-consuming mice against YAC-1 lymphoma cells was inhibited an average of 41% relative to water-drinking controls. Cytolytic activity of enriched NK cells from ethanol-consuming mice was stimulated to levels equal to control water-drinking mice after 16- to 18-hr incubation in 1000 units/ml recombinant interleukin 2. These data indicate that in vitro cytolytic activity of NK cells from ethanol-consuming mice is inhibited in the absence of other modulatory leukocytes. |
