| First Author | Osborne-Hereford AV | Year | 2008 |
| Journal | J Neuroimmunol | Volume | 193 |
| Issue | 1-2 | Pages | 130-9 |
| PubMed ID | 18077004 | Mgi Jnum | J:130590 |
| Mgi Id | MGI:3771940 | Doi | 10.1016/j.jneuroim.2007.10.029 |
| Citation | Osborne-Hereford AV, et al. (2008) Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation. J Neuroimmunol 193(1-2):130-9 |
| abstractText | The anti-inflammatory effects of the neuronal nicotinic receptor alpha7 (nAChRalpha7) are proposed to require acetylcholine release from vagal efferents. The necessity for vagal innervation in this anti-inflammatory pathway was tested in the skin, which lacks parasympathetic innervation, using ultraviolet radiation (UVB) to induce a local pro-inflammatory response. Cytokine responses to UV in mice administered chronic oral nicotine, a nAChR agonist, were reduced. Conversely, nAChRalpha7 knock-out mice exposed to UVB elicit an enhanced pro-inflammatory cytokine response in the skin. Altered pro-inflammatory responses correlated with changes in SOCS3 protein. These results demonstrate that nAChRalpha7 can participate in modulating a local pro-inflammatory response in the absence of parasympathetic innervation. |
