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Publication : Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs.

First Author  Halleck MS Year  1998
Journal  Genome Res Volume  8
Issue  4 Pages  354-61
PubMed ID  9548971 Mgi Jnum  J:47134
Mgi Id  MGI:1202652 Doi  10.1101/gr.8.4.354
Citation  Halleck MS, et al. (1998) Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res 8(4):354-61
abstractText  The Saccharomyces cerevisiae genome contains five P-type ATPases divergent from both of the well-known subfamilies of these membrane ion transporters. This newly recognized third subfamily can be further divided into four classes of genes with nearly equal relatedness to each other. Genes of this new subfamily are also present and expressed in multicellular organisms such as Caenorhabditis elegans and mammals; some, but not all, can be assigned to the classes identified in yeast. Different classes of genes and different genes within a class are expressed differentially in tissues of the mouse. The recently cloned gene for the mammalian aminophospholipid translocase belongs to this new subfamily, suggesting that other subfamily members may transport other lipids or lipid-like molecules from one leaflet of the membrane bilayer to the other.
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