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Protein Coding Gene : Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Primary Identifier  MGI:1096365 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  19188
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and pancreas. Orthologous to human PSME2 (proteasome activator subunit 2).
PHENOTYPE: Homozygous disruption of this gene results in impaired cytotoxic T lymphocyte responses and immunoproteasome assembly. [provided by MGI curators]
  • synonyms:
  • PA28b,
  • proteasome (prosome, macropain) activator subunit 2 (PA28 beta),
  • expressed sequence AI788882,
  • expressed sequence AA589371,
  • Psme2,
  • MGI:2145690,
  • AA589371,
  • MGI:2144028,
  • AI788882
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Features --> Cross References

Genome

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0 Canonical

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0 Exons

0 Genomic Clusters

1 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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