| First Author | Javelaud D | Year | 2004 |
| Journal | Int J Biochem Cell Biol | Volume | 36 |
| Issue | 7 | Pages | 1161-5 |
| PubMed ID | 15109563 | Mgi Jnum | J:90176 |
| Mgi Id | MGI:3042656 | Doi | 10.1016/S1357-2725(03)00255-3 |
| Citation | Javelaud D, et al. (2004) Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Int J Biochem Cell Biol 36(7):1161-5 |
| abstractText | Since its discovery in the early 1980s, transforming growth factor-beta (TGF-beta) has emerged as a family of growth factors involved in essential physiological processes, including embryonic development, differentiation, tissue repair and cell growth control. Knockout experiments for the three mammalian isoforms of TGF-betas in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis where, in the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface serine/threonine kinase type receptors that activate transcription factors of the Smad family. |
