| First Author | Freeley SJ | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 9 | Pages | e74112 |
| PubMed ID | 24086313 | Mgi Jnum | J:206022 |
| Mgi Id | MGI:5547666 | Doi | 10.1371/journal.pone.0074112 |
| Citation | Freeley SJ, et al. (2013) Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice. PLoS One 8(9):e74112 |
| abstractText | Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4. We examined the role of these molecules in MRL lpr mice which is one of the most established and robust murine models. We compared disease parameters in Toll-like receptor 2 or Toll-like receptor 4 deficient mice with their littermate controls. We found no difference in the severity of glomerulonephritis as assessed by histology, serum creatinine and albuminuria when Toll-like receptor 2 or Toll-like receptor 4 deficient MRLlpr mice were compared with Toll-like receptor sufficient controls. We also found similar levels of anti-dsDNA and anti-ssDNA antibodies. These results show that Toll-like receptor 2 and Toll-like receptor 4 do not play a significant role in MRLlpr mice, and therefore they may not be important in human lupus. |
