| First Author | Falcón-Pérez JM | Year | 2002 |
| Journal | Pigment Cell Res | Volume | 15 |
| Issue | 2 | Pages | 82-6 |
| PubMed ID | 11936273 | Mgi Jnum | J:76190 |
| Mgi Id | MGI:2178773 | Doi | 10.1034/j.1600-0749.2002.1r082.x |
| Citation | Falcon-Perez JM, et al. (2002) The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis. Pigment Cell Res 15(2):82-6 |
| abstractText | This review focuses on the product of the pallidin (Pldn) gene, one of a number of genes that in mice are associated with pigmentation defects and platelet dense granule deficiency. A similar combination of defects is also observed in patients suffering from Hermansky-Pudlak (HPS) and Chediak-Higashi (CHS) syndromes. Pldn encodes a novel, approximately 20-kDa protein that is expressed ubiquitously in mammalian tissues. The pallidin protein was found to bind to syntaxin 13, a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis. |
