| First Author | Andres PG | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 4 | Pages | 435-42 |
| PubMed ID | 15004555 | Mgi Jnum | J:89205 |
| Mgi Id | MGI:3039134 | Doi | 10.1038/ni1044 |
| Citation | Andres PG, et al. (2004) Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol 5(4):435-42 |
| abstractText | CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development. To define the nature of the signals that may drive different T cell responses, we have done a structure-function analysis of the CD28 cytoplasmic tail in primary T cells. CD28-mediated T cell proliferation and IL-2 production did not require a particular cytoplasmic domain. In contrast, IL-4 production was driven by the cooperative activity of specific motifs within the CD28 cytoplasmic tail. Using a gene-complementation approach, we provide evidence that one component of this T helper type 2 differentiation signal was mediated by 3-phosphoinositide-dependent protein kinase 1. Thus, different mechanisms underlie the induction of distinct T cell functional responses by CD28. |
