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Publication : A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.

First Author  Transy C Year  1987
Journal  J Exp Med Volume  166
Issue  2 Pages  341-61
PubMed ID  3036997 Mgi Jnum  J:8766
Mgi Id  MGI:57231 Doi  10.1084/jem.166.2.341
Citation  Transy C, et al. (1987) A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. J Exp Med 166(2):341-61
abstractText  We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
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