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Protein Coding Gene : Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Primary Identifier  MGI:1321159 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  19052
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables GABA receptor binding activity and protein serine/threonine phosphatase activity. Involved in T cell homeostasis; negative regulation of glycolytic process through fructose-6-phosphate; and regulation of intracellular signal transduction. Acts upstream of or within mesoderm development. Located in chromosome, centromeric region; cytosol; and plasma membrane. Part of protein phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha).
PHENOTYPE: Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed. [provided by MGI curators]
  • synonyms:
  • MGI:2144711,
  • PP2A,
  • Ppp2ca,
  • protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform,
  • R75353,
  • expressed sequence R75353

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

110 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For