| First Author | Flemming A | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 1 | Pages | 38-43 |
| PubMed ID | 12436112 | Mgi Jnum | J:80332 |
| Mgi Id | MGI:2445671 | Doi | 10.1038/ni862 |
| Citation | Flemming A, et al. (2003) The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat Immunol 4(1):38-43 |
| abstractText | Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65(-/-) pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65(-/-) mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65(-/-) pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor. |
