| First Author | Shutter JR | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 11 | Pages | 1313-8 |
| PubMed ID | 10837024 | Mgi Jnum | J:62507 |
| Mgi Id | MGI:1859030 | Doi | 10.1101/gad.14.11.1313 |
| Citation | Shutter JR, et al. (2000) Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev 14(11):1313-8 |
| abstractText | We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology. |
