| Primary Identifier | IPR030420 | Type | Family |
| Short Name | MS4A2 |
| description | The high affinity immunoglobulin epsilon (IgE) receptor (FceRI) binds to the Fc region of IgE. A typical FceRI is a tetrameric hetero-oligomer composed of an alpha chain, a beta chain, and two disulfide-linked gamma chains []. Interestingly, human monocytes, dendritic cells and Langerhans cells express FceRI without the beta subunit, employing an alphagamma2 FceRI trimeric receptor for antigen presentation []. It has been suggested that the inclusion of beta in the FceRI produces a powerful inflammatory IgE-binding tetramer restricted to mast cells and basophils, and this plays an important role in IgE-mediated allergic reaction [].This entry represents the subunit beta of the high affinity immunoglobulin epsilon (IgE) receptor (FceRI), also known as membrane-spanning 4-domains subfamily A member 2 (MS4A2). A coding variant of MS4A2 has been associated with asthma [, ]. |
