| First Author | Yeh HJ | Year | 1991 |
| Journal | Cell | Volume | 64 |
| Issue | 1 | Pages | 209-16 |
| PubMed ID | 1986867 | Mgi Jnum | J:193306 |
| Mgi Id | MGI:5468096 | Doi | 10.1016/0092-8674(91)90222-k |
| Citation | Yeh HJ, et al. (1991) PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell 64(1):209-16 |
| abstractText | Platelet-derived growth factor (PDGF) may be a critical factor in the temporal differentiation of glial elements in the mammalian central nervous system. We have used in situ hybridization and immunoperoxidase staining to investigate the localization of PDGF A and have observed high levels of PDGF A-chain mRNA and immunoreactive PDGF A in neurons of embryonic and adult mice. PDGF A-chain expression was shown to be developmentally regulated and tissue specific. Every neuronal population examined in the central and peripheral nervous systems expresses PDGF A transcripts. Variable, significantly weaker signals are observed in glial cells. In contrast to known neurotrophic factors, the PDGF A transcripts are widely distributed among neurons. This generalized distribution of PDGF A transcripts, together with the known effects of PDGF on glial cells in vitro, suggests a unique role of neurons in regulating the proliferation and differentiation of glial cells in vivo. |
