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Protein Coding Gene : Klhl41 kelch-like 41
Primary Identifier  MGI:2683854 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  228003
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Involved in several processes, including regulation of myoblast differentiation; regulation of myoblast proliferation; and skeletal muscle cell differentiation. Acts upstream of or within regulation of skeletal muscle cell differentiation. Located in M band; cytoskeleton; and sarcoplasmic reticulum membrane. Is expressed in aorta; heart; musculature; and somite. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41).
PHENOTYPE: The gene product is involved in stabilizing proteins involved in muscle function. Homozygous knockout affects the structure of muscle fibers and their sarcomeres, resulting in neonatal death. [provided by MGI curators]
  • synonyms:
  • kelch-like 41,
  • Klhl41,
  • gene model 112, (NCBI),
  • LOC228003,
  • MGI:2684958,
  • kelch repeat and BTB (POZ) domain containing 10,
  • Kbtbd10,
  • Gm112
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Features --> Cross References

Genome

Sequence Feature Displayer

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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