| First Author | Zhang J | Year | 2018 |
| Journal | Andrologia | Volume | 50 |
| Issue | 6 | Pages | e13027 |
| PubMed ID | 29700843 | Mgi Jnum | J:301738 |
| Mgi Id | MGI:6506892 | Doi | 10.1111/and.13027 |
| Citation | Zhang J, et al. (2018) Spermatogenesis-associated 48 is essential for spermatogenesis in mice. Andrologia 50(6):e13027 |
| abstractText | Azoospermia, oligospermia and teratozoospermia all seriously impact male reproductive health. Spermatogenesis is a complex and precisely regulated process in which germ cells proliferate and differentiate and involves the regulation of multiple testis-specific genes. Here, we identified testis-specific gene spermatogenesis-associated 48 (SPATA48), the expression of which was age-dependent, indicating that it is involved in spermatogenesis. In humans and mice with azoospermia, expression of SPATA48 disappeared in the testis. Spata48-/- knockout male mice had smaller testis and defective spermatogenesis compared to wild-type (WT) mice. This study can help in the exploration of the genetic basis of male infertility and identify new targets for the diagnosis and treatment of male infertility. |
