| Primary Identifier | MGI:1338016 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 12070 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). PHENOTYPE: Mice homozygous for a null allele exhibit enlarged frontal bone, dilated brain ventricle, increased stereotypic behavior, increased prepulse inhibition, decreased density in motor, cingulate and sensory cortices, and caudate-putamen, decreased total spontaneous activity frequency, and strongly reduced inhibitory postsynaptic current frequency. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
