| First Author | Yin J | Year | 2015 |
| Journal | Genesis | Volume | 53 |
| Issue | 3-4 | Pages | 278-84 |
| PubMed ID | 25711168 | Mgi Jnum | J:221428 |
| Mgi Id | MGI:5639160 | Doi | 10.1002/dvg.22847 |
| Citation | Yin J, et al. (2015) Multiple cis elements and GATA factors regulate a cuticle collagen gene in Caenorhabditis elegans. Genesis 53(3-4):278-84 |
| abstractText | The cuticle of the nematode Caenorhabditis elegans is a specialized extracellular matrix whose major component is collagen. Cuticle collagens are encoded by a large multigene family consisting of more than 150 members. Cuticle collagen genes are expressed in epidermis (hypodermis) and may be stage-specific or cyclically expressed. We identified cuticle collagen genes as transcriptional targets of the DBL-1 TGF-beta-related signaling pathway. These studies prompted us to investigate the cis-regulatory sequences required for transcription of one of the target genes, col-41. We generated reporter constructs that reproduce stage- and tissue-specific expression of fluorescent markers. We identify four conserved sequence elements that are required for transcription of reporters. Finally, we provide evidence that col-41 expression is controlled by a sequence element containing two GATA sites and by the epidermal GATA transcription factors ELT-1 and ELT-3. |
