| First Author | Caberoy NB | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 18 | Pages | 3057-62 |
| PubMed ID | 19695251 | Mgi Jnum | J:153130 |
| Mgi Id | MGI:4361052 | Doi | 10.1016/j.febslet.2009.08.015 |
| Citation | Caberoy NB, et al. (2009) Unconventional secretion of tubby and tubby-like protein 1. FEBS Lett 583(18):3057-62 |
| abstractText | Tubby-like proteins (Tulps) with no signal peptide have been characterized as cytoplasmic proteins with various intracellular functions, including binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)]. PI(4,5)P(2) has been implicated in unconventional secretion of fibroblast growth factor-2 without a signal peptide. Here, we show that all Tulps are expressed intracellularly and extracellularly. Tubby secretion is partially dependent on its PI(4,5)P(2)-binding activity with an essential secretory signal in the N-terminus. Pathogenic mutation in Tubby mice has no impact on tubby extracellular trafficking. Moreover, unconventional secretion of tubby and Tulp1 is independent of endoplasmic reticulum-Golgi pathway. These data implicate that Tulps may function extracellularly as well. |
