| First Author | Abreu-Vieira G | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 7433 | PubMed ID | 26118629 |
| Mgi Jnum | J:222846 | Mgi Id | MGI:5645761 |
| Doi | 10.1038/ncomms8433 | Citation | Abreu-Vieira G, et al. (2015) Cidea improves the metabolic profile through expansion of adipose tissue. Nat Commun 6:7433 |
| abstractText | In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative. |
